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The cervico-maxillofacial form is the most common. According to the severity of the process, a deep (muscular) form can be distinguished, when the process is localized in the intermuscular tissue, subcutaneous and cutaneous forms of Cardizem. With a muscular form, the process is localized mainly in the masticatory muscles, under the fascia covering them, forming a dense infiltrate of cartilaginous consistency in the region of the angle of the lower jaw. The face becomes asymmetrical, trismus of varying intensity develops. Then, foci of softening appear in the infiltrate, which spontaneously open, forming fistulas that separate purulent or bloody-purulent fluid, sometimes with an admixture of yellow grains (drusen).

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The cyanotic coloration of the skin around the fistulas persists for a long time and is a characteristic manifestation of actinomycosis. On the neck, peculiar skin changes are formed in the form of Cardizem arranged rollers. In the cutaneous form of actinomycosis, infiltrates are spherical or hemispherical, localized in the subcutaneous tissue.

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Lockjaw and violations of chewing processes are not observed. The cutaneous form is rare. The actinomycosis process can involve the cheeks, lips, tongue, tonsils, trachea, eye sockets, and larynx. The flow is relatively favorable (compared to other forms).

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Thoracic actinomycosis (actinomycosis of the organs of the chest cavity and chest wall), or actinomycosis of the lungs. The beginning is gradual. Weakness, subfebrile temperature, cough appear, initially dry, then with mucopurulent sputum, often mixed with blood (sputum has the smell of Diltiazem and the taste of copper). Then the picture of peribronchitis develops.


The infiltrate spreads from the center to the periphery, captures the pleura, chest wall, skin. There is swelling with extremely pronounced burning pain on palpation, the skin becomes purple-cyanotic. Fistulas develop, druses of actinomycetes are found in pus. The fistulas communicate with the bronchi. They are located not only on the chest, but can appear on the lower back and even on the thigh. The current is heavy. Without treatment, patients die. In terms of frequency, thoracic actinomycosis ranks second.

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  • Abdominal actinomycosis is also quite common (ranks third).
  • Primary foci are more often localized in the ileocecal region and in the regionappendix (over 60%), then go to other parts of the colon and very rarely affects the stomach or small intestine, esophagus.
  • The abdominal wall is affected secondarily.
  • The primary infiltrate is most often localized in the ileocecal region, often mimics surgical diseases (appendicitis, intestinal obstruction, etc.).


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Spreading, the infiltrate also captures other organs: the liver, kidneys, spine, and can reach the abdominal wall. In the latter case, characteristic skin changes occur, fistulas communicating with the intestines, usually located in the inguinal region. With actinomycosis of the rectum, infiltrates cause the occurrence of specific paraproctitis, fistulas are opened in the perianal region. Without etiotropic treatment, mortality reaches 50%.


Actinomycosis of the genital and urinary organs is rare. As a rule, these are secondary lesions during the spread of infiltrate in abdominal actinomycosis. Primary actinomycosis lesions of the genital organs are very rare.


Then the nodes soften and open with the formation of deep-reaching fistulas that secrete purulent or serous-purulent (sometimes bloody) fluid, often with a bad smell.


Next to the original nodes, new ones appear, the skin swells, the foot increases in volume, changes its shape.

Christin S.


diltiazem (maduromatosis, Madura foot) is a peculiar variant of actinomycosis. This form has been known for a long time, quite often met in tropical countries. The disease begins with the appearance on the foot, mainly on the sole, of one or more dense, delimited nodes the size of a pea or more, first covered with unchanged skin, later the skin becomes red-violet or brownish over the seals.

Barbara T.


Actinomycosis of the skin occurs, as a rule, secondary to primary localization in other organs. Skin changes become noticeable when actinomycosis infiltrates reach the subcutaneous tissue and are especially characteristic in the formation of fistulas.


It is noteworthy that despite the pronounced bone changes, patients retain the ability to move, with joint damage, the function is not seriously impaired. With the formation of fistulas, characteristic changes in the skin occur.


Osteomyelitis of the bones of the lower leg, pelvis, spine, as well as lesions of the knee and other joints are described. Often the process is preceded by trauma. Osteomyelitis occurs with the destruction of bones, the formation of sequesters.


Actinomycosis of bones and joints is rare. This form occurs either as a result of the transition of actinomycosis infiltrate from neighboring organs, or is a consequence of the hematogenous drift of the fungus.